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An example that is sometime cited is that mixed breed dogs (good old mutts) often have less genetic problems than pure breeds.
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Many pure breed dogs have severe genetic "problems".
St. Barnards, Great Danes and other large breeds suffer from hip dysplasia, a genetic weakness of the hindquarters. Honest breeders try to keep it out of their lines.
Collies have been so inbred in search of the "perfect" long narrow pointed nose, that it is almost impossible to find one without one or more genetic defects.
Cocker Spaniels, once a hunting dog, have been bred for "cuteness" to the point that some say "they've bred the brains out of them".