While in the short term there might be an increase in population, investing that amount of money should hasten the demographic transition in developing countries and reduce the overall population of the world in the medium to long term. Mind you, racist loonies aren't likely to listen to reason.

Drake and many of his crew became extremely rich, however, the black death, fire of London and wars seemed to have much larger economic effects than Drake returning with a hold full of booty. This makes me think he didn't actually have 5 times England's GDP. When you consider that the population was around three million, and the average Englishperson might engage in a pound's worth of economic transactions a year, 5 years GDP might be around 15 million pounds of silver, or about 7 million metric tons. I doubt he had 7 million metric tons of silver. With an exchange rate at the time of roughly 20.8 pounds of silver to a pound of gold that would be over 300,000 tons of gold. The Golden Hind had a displacement of about 300 tons.