I disagree. I think safety will force them to focus on simpler systems instead of more complicated systems that have more things that can fail. Simpler systems will make space access cheaper, which will make a mission to mars cheaper as well as safer.

Perhaps the shuttle being safe is a fraud, but future spacecraft need not be fraudulent in terms of safety.

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"What you think you thought you saw you did not see." Agent J, MiB - Manhatten Bureau