Orson Scott Card says that
all science is a game! (It's a long article. I suggest scrolling down to the section titled "Why Faith in Darwinism Is No Better".)
They may disguise these assumptions by speaking of "elegant" solutions, or "symmetry," but the fact is that scientists commonly expect the universe to make sense. And "making sense" is a very unscientific idea.
Science thus becomes a game – you are allowed to play only within the rules.
I disagree with almost everything he says about science, but it's still an interestingly different viewpoint.