Perhaps your definition of 'not significantly different' is significantly different to mine. I would suggest that since all categories of life on this planet are endemic to our planet, that is to say, not found anywhere else, we will certainly be significantly different to life elsewhere.
To put it explicitly; there are no, and there will never be, any members of the kingdom Animalia anywhere else in the universe unless they travel from Earth in some way.
There are not, and there will never be, any members of the phylum Chordata anywhere else in the universe unless they travel from Earth in some way.
there are not, and there will never be, any members of the class Mammalia anywhere else in the universe unless they travel from Earth in some way.
there are not, and there will never be, any members of the order Primates anywhere else in the universe unless they travel from Earth in some way.
there are not, and there will never be, any members of the species Homo sapiens anywhere else in the universe unless they travel from Earth in some way.
There may be animal-like, vertebrate-like, mammal-like, and human-like (or humanoid) species out there, but in my opinion they get increasingly unlikely as the level of complexity increases.
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