Home Improvement had an episode where the actual crew of Hubble Servicing Mission 1 guest-starred and their were a few very funny bits:

Tim: "I'm going into space!"
His wife: "How soon can you leave?"

Tim: "What's it like working with tools in space?"
Mission Specialist: "It's a lot like working with tools on Earth, except you don't have to worry about dropping anything on your foot."
Al: "Gee, sounds like the perfect place for you, Tim."

And then there was a bit where the crew all introduced themselves and Tim made jokes about their names. These were the only two I remember:

Ken Bowersox: "They call me 'sox' for short."
Tim: "Is that because you never change your socks when you're in space?"

Tim: "What's the story, Story?"
Story Musgrave: "Gee, never heard that one before."

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