Just installed it now. Very clean interface, with auto-updating and even real-time protection, which is offered with Ad-aware in the paid version only.

EDIT: lol just discovered one problem, albeit its on the false positive side which isn't so bad. I installed Kazaa lite to see if it would detect it as spyware/adware. And it did. (for those who don't know, Kazaa lite is a spyware-free version of Kazaa). None of the other antispyware programs detects this as spyware normally.

Second Edit: The program detected 2 other spyware/adware items that Ad-aware and Spybot didn't detect. Cleaned them out, and allows you to configure your browser in one small Window (with the homepage, search page, etc) after you remove a browser hijacker. So far so good.