I think Star Trek ran it's course. I thought the idea behind Enterprise - the era before the TOS - had promise but it never took off. Shallow plots/acting didn't help, but I think the main problem was the simple fact that after TOS and TNG the Trek-cow was milked dry (so to speak). I never liked Andromeda so maybe I'm biased here, but I don't think a post-Federation angle would work any better than Enterprise, Voyager, or DS9 did.