Negative do not use a vacuum cleaner to clean out your computer. There is a huge static charge that builds up in the hose and you can and will fry your machine.

The problem with using a compressor is the little bits of metal that are shaved off the compressor piston and they will lodge into the tiny components in you main board and cause a short.

Here is a tip. Get a good furnace filter and cut out pieces big enough to fit into your vents on your computer. This will reduce the amount of dust that gets into your machine and keep it clean longer without reducing your airflow to much. Also do not keep your machine on the floor have it on a stand so it is not directly on the floor.

PLEASE DO NOT USE A VACUUM CLEANER

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Just because something is improbable Doesnt mean its impossible.