An interplanetary ship does not need heavy thrust. it can be powered by ionic or plasmic motors.So structural problems can be kept at a minimum.

It can go edge on , and the edge can be fit with a shield.

Problem , the disk configuration is not very efficient to pack living space inside your ship. A sphere is better.

Then there is the dangers of having rockets motors just next crew's bunks inside the habitable part of the ship.

THe 2001 design is much better IMO.