Quite a few, in fact.

Years ago my wife and I went to see Mort at our local theatre. According to the bill it was performed by a youth group or something, so we were expecting late teens and early 20s. Turned out it was schoolchildren. (The head teacher played Death.)

It was entertaining, and it would be very churlish to dismiss the acting skills of schoolkids who were doing their best. But it was very much a school play, and we hadn't expected that.

At the same venue a few years later, we saw Weird Sisters, which was done extremely well. The only thing was, nobody was laughing at the jokes. I felt sorry for the actors, especially the woman who played Granny Weatherwax, because I knew her. The thing was, I think we were all getting into the story (and consequently enjoying it) but the jokes have been copied by others since the book came out, and consequently they are too familiar to have audiences rolling in the aisles.

[Snip an addition that would probably annoy people because it mentions a fantasy novel that someone is bound to want to quote.]