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Isn't what you're talking about more related to density than gravity?
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Well yeah. But if your body is less dense than the water surrounding it, you will float up and therefore you wouldn't need strong bones or whatever to deal with gravity pushing you down.
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Gravity would have a major effect on the pressure (psi) of water at 2.2X relative to the pressure on Earth.
Swimming at 50 feet there for a human would be like diving to 110 feet here.
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Hmm. Hadn't thought of that. Of course, the exact numbers would also depend on how much atmosphere that planet has...
but anyway, human-like organisms could live in shallow seas (assuming there are any) or just generally near the surface, and the pressure changes wouldn't affect them too much. Or there could be organisms similar to deep-sea fish, or those which migrate (here on earth) from the deep ocean to the surface each night (or like sperm whales, which dive down deep in order to find Squid and other things to eat)... They'd have to be careful about pressure, but I don't think the changes would be too drastic...no? I still think organisms would be less affected by gravity than if they lived on land.
And they could certainly have soft bodies and be huge.