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Old 10-March-2008, 07:22 AM
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Default Pharmaceutical pollution in drinking water

I just read this here and was wondering what y'all think.

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In the course of a five-month inquiry, the AP discovered that drugs have been detected in the drinking water supplies of 24 major metropolitan areas — from Southern California to Northern New Jersey, from Detroit to Louisville, Ky.

Water providers rarely disclose results of pharmaceutical screenings, unless pressed, the AP found. For example, the head of a group representing major California suppliers said the public "doesn't know how to interpret the information" and might be unduly alarmed.

How do the drugs get into the water?

People take pills. Their bodies absorb some of the medication, but the rest of it passes through and is flushed down the toilet. The wastewater is treated before it is discharged into reservoirs, rivers or lakes. Then, some of the water is cleansed again at drinking water treatment plants and piped to consumers. But most treatments do not remove all drug residue.

And while researchers do not yet understand the exact risks from decades of persistent exposure to random combinations of low levels of pharmaceuticals, recent studies — which have gone virtually unnoticed by the general public — have found alarming effects on human cells and wildlife.
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Old 10-March-2008, 09:01 AM
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Not mentioned as well: the mechanism in the news a few months ago, people dispose of unused pills in the toilet. In those stories we were advised to use garbage to dispose of pills, and to make the pills unusable by mixing with used cat litter or other foul matter.

MSNBC: Don’t flush leftover meds — mix with kitty litter

Quote:
Experts say icky disposal method safer for kids and environment

Mixing cough syrup, Vicodin or Lipitor with cat litter is the new advice on getting rid of unused medications. Preferably used cat litter.
I'm finding it's a great way to meet your new neighbors -- coming over to borrow a cup of used kitty litter.
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Old 10-March-2008, 09:17 AM
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According to my pharmacist (I'm on very good terms with my pharmacist, as I'm sure you can imagine), you shouldn't throw them away, either, because they'll dissolve and end up the in the groundwater anyway. I should imagine it's a bigger problem here, because our water table is awfully high. In fact, you're supposed to take them to a specified disposal site, where--I believe--they burn them. However, the nearest disposal site for me is at McCord Air Force Base, up near Tacoma, so it's a bit out of my way.
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Old 10-March-2008, 09:39 AM
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Drugs have been detected? Pronouncements like that always make me think to myself - what are the detectable limits involved?

From the article:

"To be sure, the concentrations of these pharmaceuticals are tiny, measured in quantities of parts per billion or trillion, far below the levels of a medical dose."

I think I'll worry about something else.
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Old 10-March-2008, 10:03 AM
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Quote:
Originally Posted by Gillianren View Post
According to my pharmacist ..., you shouldn't throw them away, either, because they'll dissolve and end up the in the groundwater anyway. ... In fact, you're supposed to take them to a specified disposal site, where--I believe--they burn them. However, the nearest disposal site for me is at McCord Air Force Base, up near Tacoma, so it's a bit out of my way.
Over here you are supposed to return unused medication to the pharmacist and they then ship it to a disposal facility.
I'm sure that that has more to do with safety, then environmental concerns.

On another note, apparently removing the components from urine itself is the most expensive phase of cleaning water.
A separate infrastructure to collect urine is however economically non-viable. (For now.)
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Old 10-March-2008, 01:57 PM
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"To be sure, the concentrations of these pharmaceuticals are tiny, measured in quantities of parts per billion or trillion, far below the levels of a medical dose."

I think I'll worry about something else.


On CNN Headline News this morning, they explained that you'd have to drink anywhere from 300,000 to 3 million glasses of water to get the equivalent dosage of one 81 mg aspirin. Admittedly, there are some medications that are effective at lower dosages than that aspirin but your point remains - this dosage is soo low that you'll die of water intoxication long before you even begin to approach even the lowest threshold of human sensitivity to the medications.

When you can detect stuff in the parts per billion or parts per trillion range, you'd going to find all sorts of things in the air, in your water, and in your food. Just remember the old axiom - its the dose that makes the poison.
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Old 10-March-2008, 02:55 PM
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I find it interesting that we can detect organic molecules at the part per trillion level.
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Old 10-March-2008, 02:55 PM
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I find this unsurprising. It has been know for several years that various pharmaceuticals were found in sewer discharges (even from treated sewage). It makes sense that it would show up in drinking water. To the best of my knowledge, most water treatment systems (either for drinking water or sewage) are not designed to deal with these contaminants.

On the flip side, I wouldn't lightly dismiss the effects of parts-per-billion contaminants. Sure, it is not going to be a therapeutic dose. But some of these pollutants have been found to have effects on wildlife at levels found in our water supplies. And while the individual glass of water will have very little of any given pharmaceutical, their may be combined effects from many different ones and from cummulative effects over many years.
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Old 10-March-2008, 02:56 PM
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Quote:
Originally Posted by jlhredshift View Post
I find it interesting that we can detect organic molecules at the part per trillion level.
That ability has existed for years, particularly if you know exactly what you are looking for.
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Old 10-March-2008, 02:59 PM
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Old 10-March-2008, 03:35 PM
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Quote:
Originally Posted by Swift View Post
That ability has existed for years, particularly if you know exactly what you are looking for.
Are they looking for the "exact" molecules by proxy or are they segregating and then measuring?
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I know you are a person who takes his physics seriously, but isn't it said that most great discoveries aren't discovered with "Eureka!" but with, "Hmmm, that's funny." Big Don
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Old 10-March-2008, 06:28 PM
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Quote:
And while researchers do not yet understand the exact risks from decades of persistent exposure to random combinations of low levels of pharmaceuticals, recent studies — which have gone virtually unnoticed by the general public — have found alarming effects on human cells and wildlife.
What recent studies, what effects, and what is the threshold level of "alarming"?
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Old 10-March-2008, 07:01 PM
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Quote:
Originally Posted by Larry Jacks View Post
On CNN Headline News this morning, they explained that you'd have to drink anywhere from 300,000 to 3 million glasses of water to get the equivalent dosage of one 81 mg aspirin.
There, that's the kind of reality I was looking for.
So; 1 aspirin for an entire lifespan.

Quote:
Originally Posted by Larry Jacks View Post
Admittedly, there are some medications that are effective at lower dosages than that aspirin but your point remains
I would think that the more potent the medicine, the less likely it would be introduced/prescribed, and therefore not be a larger threat.

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Originally Posted by Swift View Post
On the flip side, I wouldn't lightly dismiss the effects of parts-per-billion contaminants. Sure, it is not going to be a therapeutic dose. But some of these pollutants have been found to have effects on wildlife at levels found in our water supplies.
Compared to everything else we do to the environment, I bet it's only a drop in the bucket (pun intended).


From the article:
Quote:
Pharmaceuticals also can produce side effects and interact with other drugs at normal medical doses. That's why — aside from therapeutic doses of fluoride injected into potable water supplies — pharmaceuticals are prescribed to people who need them, not delivered to everyone in their drinking water
Excuse me? Flouride has been shown to fullfill a need to society (suposedly everyone benefits). That's not true of pharmaceuticals.
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Old 10-March-2008, 07:50 PM
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Back in the 1970s, there was a study that claimed a link between drinking sodas sweetened by sacarine and bladder cancer. It turned out that a person would have to drink the equivalent of over 700 sodas a day for years to run an increased cancer risk. Some people immediately began pressing for a ban on sacarine. I looked at those numbers and thought sacarine must be incredibly safe for it to take so much to cause a cancer risk. In fact, I never used the product until that study showed it was so safe.

If you're having to go to the parts per billion or parts per trillion to detect something in drinking water, that to me says the stuff is about as safe as it's humanly possible to make anything.
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Old 10-March-2008, 07:54 PM
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Quote:
Originally Posted by jlhredshift View Post
Are they looking for the "exact" molecules by proxy or are they segregating and then measuring?
I'm not sure what you mean by proxy? There are two ways one might approach this, you check a water sample for whatever you can find in it (look for everything) or you can check for a specific compound. The look for everything approach is much more diificult, particularly for the hundreds of thousands of organic compounds known. So you have to use some pretty broadly applicable methods and your detection limits are not as good.

I don't know how they did this study, but I suspect they went looking for specific things. Maybe picked the top ten or twenty most widely used drugs and went looking for those. There are methods for searching for specific compounds that are good to parts-per-billion levels or better.

In the next week or two, some of the weekly science publications I get (such as Science News and Chemical & Engineering News) should have this story with, I assume, a lot more detail.
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Old 10-March-2008, 08:02 PM
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I think the concern may be more about the potential future hazard as more people take more medicines, putting more into the sewage system, and possible drug interactions.
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Old 10-March-2008, 08:07 PM
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And also from the accumulation of certain drugs that don't degrade.
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Old 10-March-2008, 08:15 PM
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Quote:
Originally Posted by Noclevername View Post
What recent studies, what effects, and what is the threshold level of "alarming"?
See my link above for one reference.

Another report (2005) on environmental effects from the Environmental Health Perspectives On-line.
Quote:
So far there is no evidence of adverse human health effects due to traces of pharmaceuticals in water. But scientists have linked certain pharmaceuticals with disturbing ecosystem changes. For example, in volume 8 (1994) of Chemistry and Ecology, researchers demonstrated that the feminization of fish--male carp and trout producing vitellogenin, an egg protein usually found only in females--was associated with exposure to sewage effluent now known to contain ethinyl estradiol, the active ingredient in birth control pills.
I have read multiple studies like this and many were done at concentrations found in these ecosystems (parts-per-billion). For example, there is this one from Science News from 2003.
Quote:
Of 21 fish captured downstream of a Denver water-treatment plant, 81 percent were females and all of the males there had testes containing ovarian tissue.
This is from the University of Arizona, Water Resources Research Center
Quote:
What risk does chronic exposure to trace concentrations of pharmaceuticals pose to humans or wildlife? Some scientists believe pharmaceuticals do not pose problems to humans since they occur at low concentrations in water. Other scientists say long-term and synergistic effects of pharmaceuticals and similar chemicals on humans are not known and advise caution. They are concerned that many of these drugs have the potential of interfering with hormone production. Chemicals with this effect are called endocrine disrupters and are attracting the attention of water quality experts.

To some scientists the release of antibiotics into waterways is particularly worrisome. They fear the release may result in disease-causing bacteria to become immune to treatment and that drug-resistant diseases will develop.

Scientists generally agree that aquatic life is most at risk, its life cycle, from birth to death, occurring within potentially drug-contaminated waters. For example, anti-depressants have been blamed for altering sperm levels and spawning patterns in marine life. Most studies of pharmaceutical and pharmaceutically active chemicals in water have mostly focused on aquatic animals.
I personally think the synergistic effects of multiple contaminants over long periods of time are the most potentially troubling concern.
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