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Old 02-November-2006, 01:10 AM
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Default Red wine molecule helps mice live longer

Red wine molecule helps mice live longer

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A compound in red wine and grapes can extend the life span of obese mice and help them enjoy a healthier old age, scientists say.

The molecule known as resveratrol not only enabled the mice to live longer than other overweight rodents, it also reduced the negative health effects of eating a high-calorie diet.
[...]
"The real bang will be if somebody proves this is going to work in people," Sinclair adds.
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Old 02-November-2006, 04:10 AM
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Speaking of wine, I'd like to start drinking red wine on a regular basis, but I don't like the taste. Is there anything I can do to make it taste better? How much would I need every day to get the ideal health benefits, and how much would it cost/month? I have a tight budget.

- Maha Vailo
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Old 02-November-2006, 04:26 AM
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Every time people find another benefit of fruit, fruit skins, fruit juice, or such, they report it as a benefit of wine. How many more excuses do we need to make for alcohol?
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Old 02-November-2006, 04:31 AM
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Originally Posted by Maha Vailo View Post
Speaking of wine, I'd like to start drinking red wine on a regular basis, but I don't like the taste. Is there anything I can do to make it taste better?
Sangria! Might as well get some real fruit juice with your red wine.

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Originally Posted by Maha Vailo View Post
How much would I need every day to get the ideal health benefits, and how much would it cost/month? I have a tight budget.
A summarizing report on the story I heard gave the human-daily-red-wine-bottle equivalent for the amount of chemical the mice were given: 100 bottles. Hic!
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Old 02-November-2006, 05:36 AM
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...I'd like to start drinking red wine on a regular basis, but I don't like the taste...I have a tight budget.
There's quite a taste gamut with reds; I find a Merlot to be a smooth and tasty middle-ground.
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Old 02-November-2006, 12:11 PM
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A summarizing report on the story I heard gave the human-daily-red-wine-bottle equivalent for the amount of chemical the mice were given: 100 bottles. Hic!
So, it can't be done under mortal circumstances? Well then, where could I get a concentrate of the chemical in question? If even that is impossible, what practical ways are there of extending my lifespan exist out there that I can do right now?

- Maha "live long and prosper" Vailo
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Old 02-November-2006, 12:16 PM
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what practical ways are there of extending my lifespan exist out there that I can do right now?
Exercise, eat a modest, varied diet, and ignore hyped media reports about the health benefits of Foods X, Y and Z.
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Old 02-November-2006, 01:25 PM
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Try Mogen David; it may be too sweet for your tastes.

I am personally willing to embark on a study of the health benefits of drinking copius amounts of red wine on a daily basis.

(Actually, I think I did this once or twice before, but the memories are hazy.)
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Old 02-November-2006, 01:28 PM
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Exercise, eat a modest, varied diet, and ignore hyped media reports about the health benefits of Foods X, Y and Z.
Aw, c'mon! There's got to be something beyond that! I've known a lot of people who've done exactly what you described and yet still lived an average lifespan. I'm talking about livng to 90-100 or beyond here. Is there any secret to doing that? I'd really like to know.

- Maha "I'm 33 for a moment..." Vailo
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Old 02-November-2006, 02:50 PM
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Quote:
Originally Posted by sarongsong View Post
Quote:
Originally Posted by Maha Vailo
...I'd like to start drinking red wine on a regular basis, but I don't like the taste...I have a tight budget.
There's quite a taste gamut with reds; I find a Merlot to be a smooth and tasty middle-ground.
What sarongsong said. What don't you like about reds - is it the dryness (lack of sweet), is too bitter or too acidic? Whites have a big range too - which whites do you like? Given what you don't like, a decent wine shop could recommend a wine you would like, even at a very reasonable cost.
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Old 02-November-2006, 04:15 PM
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It's one of those things, if you don't drink alcohol in the first place it's definately not worth starting just because of some supposed health benefits. Dark grape juice would be just as healthy.

As far as good red wines, I really like Lambrusco, and it can be found pretty cheap (I usually get it for about $4 a bottle at kroger). Very good with a pasta dinner.
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Old 02-November-2006, 04:19 PM
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Well then, where could I get a concentrate of the chemical in question? If even that is impossible, what practical ways are there of extending my lifespan exist out there that I can do right now?
Here's drinking to your health: Study finds red wine benefits

Quote:
The researchers cautioned that the findings should not encourage people to eat badly, thinking resveratrol could make gluttony completely safe. They also noted that a person would have to drink at least 100 bottles of red wine a day or take mega doses of the commercially available supplements to get the levels given to the mice, which may not be safe in humans.

But the findings indicate that resveratrol or molecules like it could have myriad benefits, and several aging researchers said the results tempted them to start using the supplements in the meantime.

"I'm usually a very cautious person," said Cynthia Kenyon of the University of California in San Francisco. "But I'm seriously thinking about taking resveratrol myself. It seems pretty wonderful."

"I actually told my mother she should take it," Helfand said. "I even went out and got her some."
I would wait for human studies. Dietary supplements are such shady business.

If you want to investigate a promising life extension technique, investigate calorie restriction -- if you can call that living.
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Old 02-November-2006, 04:34 PM
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[QUOTE=01101001;858409]
I would wait for human studies. Dietary supplements are such shady business.
QUOTE]

Deffinately agree. The majority of these products turn out to have no actual benefits whatsoever, or worse are recalled after they are found to actually cause worse health problems. I remember when I was in police academy, I developed a knee injury after running so many miles a day when my body wasn't accustom to it. The doctor i saw put me on Naproxin (sp?), an anti-inflamitory to fight the swelling and spasiming in my leg muscles. I didn't end up using it and just worked through the pain, which is good because a few months later the drug was recalled after being linked to several deaths from heart something or other. Stupid medical science!

Of course we wouldn't be where we are today if not for all the brilliant medical discoveries, but its always best to approach new information with cautious skeptisism.

On a side note: I wouldn't mind being the one who got to run these tests. How much fun would it be to get a bunch of fat little mice drunk and dress them in mini togas so they can re-inact "Animal House"? LoL
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Old 02-November-2006, 06:38 PM
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...what practical ways are there of extending my lifespan exist out there that I can do right now?...
Durk Pearson and Sandy Shaw's Life Extension: A Practical Scientific Approach [1983] has quite a bit to say on the subject, and has blossomed into a non-profit (commercial) operation:
Quote:
The Life Extension Foundation is the largest organization dedicated to investigating every method of extending the healthy human life span... LEF
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Old 02-November-2006, 06:45 PM
Maha Vailo Maha Vailo is offline
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"Life extension"-type therapies tend to be expensive quackery. I won't touch them.

Also, I'm not sure how to do a calorie-restriction thingy and still remain hale, healthy, and (most importantly) full, although it would definitely save me money on food. Any tips?

- Maha (diets must be practical as well as effective) Vailo
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Old 02-November-2006, 08:39 PM
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Quote:
Originally Posted by Jim View Post
Try Mogen David; it may be too sweet for your tastes.

I am personally willing to embark on a study of the health benefits of drinking copius amounts of red wine on a daily basis.

(Actually, I think I did this once or twice before, but the memories are hazy.)
Why experiment on mice ? There is a mass experiment on human currently being done in France , started some centuries ago and still going on ! I confess I am not a big experimenter , being more a beer man but never refuse to help ! There is some difference of opinion about the result , sure it explain why the experiment is still on . Anyway some popular conclusions have been reached : "Le vin c'est la France , l'eau c'est la soufrance" , "Quand c'est du bon , ça peut pas faire de mal " , "Buvez toujours du vin avec votre repas sinon vous risquez de péter de la poussière !" and so on . . .
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Old 02-November-2006, 11:37 PM
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"Life extension"-type therapies tend to be expensive quackery. I won't touch them...
Well, I really don't see how the final results could be in yet. Perhaps the Hunza Diet might be more palatable since its adherents' (the Hunza people) results are in. (Don't forget the natural glacier water.)
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Old 03-November-2006, 01:20 AM
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For those interested, the compound is actually a fairly simple stilbenoid.
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Old 03-November-2006, 01:38 AM
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Durk Pearson and Sandy Shaw's Life Extension: A Practical Scientific Approach [1983] has quite a bit to say on the subject, and has blossomed into a non-profit (commercial) operation:
I have that book. Interesting read. Unfortunately, I haven't seen evidence that megadoses of vitamin E and other suggestions in there have a significant effect on extending lifespan, and it could be actively dangerous. Extreme calorie restriction is about the closest thing to being demonstrated as possibly extending lifespan beyond just being careful, not smoking, exercising, etc. Even that hasn't been actually demonstrated in humans, and I couldn't live with what is essentially a starvation diet with supplements. Given a choice, very few do.
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Old 03-November-2006, 01:42 AM
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Well, I really don't see how the final results could be in yet. Perhaps the Hunza Diet might be more palatable since its adherents' (the Hunza people) results are in. (Don't forget the natural glacier water.)
The results are in? Where?

I notice that page has a link to a quakery watch page on Young:

http://70.103.16.21/Quackerywatch/Yo...ealth2004.html

From there:

In his Toronto lecture, Gary Young showed a photograph of a man that he identified as Cherile [sic], and reported the man’s age as 168 years old at the time of the photo. The man in the photograph appeared to be Shirali Mislimov. [snip]

First, the Azerbaijan authorities did not permit any western journalists or medical men to interview him because they felt that Mislimov was too frail. Second, Mislimov died in 1973. Per Young’s autobiography, Young was hit on the head by a falling tree in February 1973 and spent months in the hospital, then was paralyzed for several years.

Per Young’s autobiography, he did not embark on his purported studies of health and longevity until several years AFTER the 1973 accident.
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Old 03-November-2006, 05:38 AM
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The results are in? Where?...
Lots of places:
Hunza Health Secrets for Long Life and Happiness [1978] , for one,

and another:
Quote:
Hunza is located in a remote valley some 200 mi. long but only one mi. wide. It is situated at an elevation of 8,500' and is completely enclosed by mountain peaks...as high as 25,550'...The average age is 90 when they die. Dr. Alexander Leaf, Chief of Medical Services at Massachusetts General Hospital and a professor at Harvard Medical School, has reliably reported meeting a 106-year-old man..."the fitness of many of the elderly rather than their age that impresses me,"...out of a present population of 40,000, 6 men are over 100 years of age...In America, by contrast, there are only 3 centenarians for every 100,000 people... Trivia-Library
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Old 03-November-2006, 07:06 AM
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Lots of places:
Hunza Health Secrets for Long Life and Happiness [1978] , for one,

and another:
No, I'm asking for careful research based on good documentation, not word of mouth, as was done in Hunza. "Age stretching" is a pretty common practice in places that don't have really good record keeping.

I remember the flap about the National Geographic article (Alexander Leaf), and from here:

http://en.wikipedia.org/wiki/Longevity_myths

A National Geographic article in 1973 treated with respect some claims subsequently disproven, including the notorious Vilcabamba valley in Ecuador, where locals claimed ancestors' baptismal records as their own. That article also reported of very aged people, the Hunza in a mountain region of Pakistan, without documentary evidence being cited.

It is typical that extreme longevity claims come from remote areas where recordkeeping is poor, but generally observed life expectancy is rather lower than in the areas where genuine claims are typically found. The Caribbean nation of Dominica was lately promoting the allegedly 128-year-old Elizabeth Israel (1875??–2003) but has a smaller population and lower life expectancy than Iceland, where the documentation is very good and life expectancy is very high yet the longevity record is 108.
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Old 03-November-2006, 05:22 PM
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Heh, I stumbled upon this link today. I think if we read the OP and follow it up with this article, we can put two and two together and all come to the same conclusion:

If we humans would spend more time sitting in our freezers while drinking wine, we'd all live forever.

Also, Eskimos in the cold northern alaskan wilderness (I use them as an example because i'm posting from the US, but any cold icey region will do) that are also afflicted with alchoholism will outlive us all.
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