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Old 11-August-2008, 11:32 PM
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Default Scientists have stopped the aging process in an entire organ

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Aging Process Halted in Mouse Liver
ABC Science Online/AFP

Aug. 11, 2008 -- Scientists have stopped the aging process in an entire organ for the first time, a study released today says.

Published in today's online edition of Nature Medicine, researchers at the Albert Einstein College of Medicine at Yeshiva University in New York City also say the older organs function as well as they did when the host animal was younger.

The researchers, led by Associate Professor Ana Maria Cuervo, blocked the ageing process in mice livers by stopping the build-up of harmful proteins inside the organ's cells.

More at http://dsc.discovery.com/news/2008/0...ing-cells.html
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Old 12-August-2008, 06:07 AM
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Is that good news or what ? Can it stop the skin cells from aging too , so that I will not worry of the wrinkles when I get old ?

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Old 12-August-2008, 06:27 AM
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And can we get the opposite if we want?
I'm tired of getting carded for milk.
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Old 12-August-2008, 09:49 AM
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Neat!
I'm cautiously optimistic with that one.

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Old 12-August-2008, 11:42 AM
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Like we aren't overpopulated enough now... like we need Lazarus Longs running around.
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Old 12-August-2008, 02:43 PM
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It is interesting, but for me this does not raise any immortality bells.
People will still find ways of removing themselves from the gene pool.
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Old 12-August-2008, 03:02 PM
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This only addresses one aspect of aging, the buildup of waste products in cells. Fixing this would probably extend life a bit, but not make you immortal. The important thing is that it might dramatically improve quality of life for older people.
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Old 13-August-2008, 12:47 PM
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Doesn't stop the telomere clock though.
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Old 14-August-2008, 02:10 AM
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Doesn't stop the telomere clock though.
Exactly, and it's the REAL limiting factor
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Old 12-January-2009, 08:44 PM
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Shucks--no chance for me to see Tanhauser gate then...
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Old 13-January-2009, 12:05 AM
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You mean there's something behind all the liver detox efforts along fringe lines?

Hmmm...

I found the following very interesting:

Quote:
"She has single-handedly shown that lysosome function is a crucial part of the ageing process," he said.

He added, Cuervo has also shown the critical role the lysosomal receptor molecules play in keeping the liver clean of damaged proteins.

While her paper does not show increased survival rates among the mice, le Couteur, who has advised her recently on the research, says Cuervo does have data on improved survival rates which she intends to publish.

Cuervo is now working with pharmaceutical companies to identify drugs that will turn the receptors on, or make them more active. She believes maintaining efficient protein clearance may improve longevity and function in all the body's tissues.

It is also possible that the same kind of "cellular clearance" can be achieved through diet, she said. Research over the past decade has shown that restricted calorie intake in animals, including mammals, significantly enhances longevity.

"My ideal intervention in the future would be a better diet rather than a pill," she said.
Diet? Really?

Hmmm...
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Old 13-January-2009, 12:44 AM
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OK, suppose a human or other animal were to live long enough to have their telomeric clock run out on them. Would the effects be similar to the cessastion of cell division by other agents (like radiation), or would it be different?

- Maha (so much for never dying) Vailo
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Old 13-January-2009, 05:01 AM
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Originally Posted by Maha Vailo View Post
OK, suppose a human or other animal were to live long enough to have their telomeric clock run out on them. Would the effects be similar to the cessastion of cell division by other agents (like radiation), or would it be different?

- Maha (so much for never dying) Vailo
Howdy Maha,

The best answer I have after near twentyeight years of keeping small animals, often well past their normal experation dates in natural settings, is that it comes on as multiple illnesses all at once as the immune system malfunctions. That's what I was told happens to them at extreme age by several doctors who were regular customers. I had a lady come to me because her betta was sick (siamese fighting fish) and none of my usual remedies helped.

When it died she came in all sad and said she remembered just like yesterday when she bought that fish five years earlier. This animal's normal life span is two years. I had set aside a very nice blue and red one for her. Told her to keep doing what she was doing.
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Old 13-January-2009, 05:18 AM
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Originally Posted by ryanmercer View Post
Like we aren't overpopulated enough now... like we need Lazarus Longs running around.
Sounds like a fantastic reason for colonising places other than the Earth.

Does anyone have any good places on the net to read about Telomeres? Not a lot seems to be coming up.
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Old 13-January-2009, 05:23 AM
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nevermind .. found one
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Old 13-January-2009, 07:53 AM
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Sounds like a fantastic reason for colonising places other than the Earth.
I dunno Josh, (Long time no see, I think. ) You want to live nine hundred years in a freezing, low pressure hell hole or a boiling, acidic hell hole?

I'll move over before condemning someone to that.
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Old 13-January-2009, 08:07 AM
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Quote:
Exactly, and it's the REAL limiting factor
Except in some birds where telomeres get longer as the bird gets older. These birds do live a long time for a petrel (20 years) but not long compared to many parrots and they still conk out eventually.
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Old 13-January-2009, 10:58 PM
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Most people think of colonizing space as if we were little fishies going from a lake in Iowa to a lake in California. When in actuality you are going from said lake in Iowa to which you are perfectly adapted to, into somebodies fishtank.

Ever see a fishtank you would drink out of?
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Old 13-January-2009, 11:10 PM
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Demographically, overpopulation is a myth. Birthrates are already below replacement levels in the vast majority of the developed world, and as developing countries begin to match pace, their birthrates will fall, too. I believe that the UN projects the human population to cap out in the mid-2020s, with the population falling after that.

Also, say that ageing was totally stopped in humans. Don't you think that would cause other demographic shifts, as lifespans would be, on average, around 3 to 6 centuries (that's about how long you get until you're hit by a bus, or somesuch)?
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Old 14-January-2009, 01:41 AM
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Quote:
Originally Posted by BigDon View Post
Most people think of colonizing space as if we were little fishies going from a lake in Iowa to a lake in California. When in actuality you are going from said lake in Iowa to which you are perfectly adapted to, into somebodies fishtank.

Ever see a fishtank you would drink out of?
We stay here and we're asking to be wiped out.

(and good to be back!! missed the place!)
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Old 14-January-2009, 02:47 AM
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We stay here and we're asking to be wiped out.

(and good to be back!! missed the place!)
By what pray tell? Hasn't happened in five million years. That's telling all by itself.

Even after a Chixilub sized event the Earth is STILL more habitable than Mars or Venus ever will be. Who do you recommend we send first to Mars? I don't think the ol trick of emptying the prison systems into the new colonies will work for this one.

Even the Irish would go, "Hey...wait a minute..." Though suspended animation would be easier to maintain with those guys as long as the "bio-reactor" kept producing by-products of bacterial respiration in response to sucrose metabolism.





Yes, I was "smiling when I said that".

I've run into several Irishmen (not Irish-Americans) in my life who had absolutely no sense of humor whatsoever, nor use for anybody that does have one. Guys on the lam from "The Troubles" and all. Had to find out on my own not to muck with those guys. Or to talk politics with them like they were merely the opposite political party. Yeah, there is a story here but it's a long one.
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Old 14-January-2009, 03:14 AM
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World population is expected to peak at about 9.75 billion around 2050. Percentage growth of world population is now way below the peak it reached in the 80's.
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Old 14-January-2009, 04:35 AM
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2050, pardon me. Thanks.
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Old 14-January-2009, 06:13 AM
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By what pray tell? Hasn't happened in five million years. That's telling all by itself.
Does that mean we're due? What's the point in putting all your eggs in one basket?
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Old 14-January-2009, 06:46 AM
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Does that mean we're due? What's the point in putting all your eggs in one basket?
Ah, but that basket is 8,000 miles across and weighs seven with a butt load of zeros after it long tonnes. You got a better one?
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Old 14-January-2009, 04:42 PM
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Don, extinction-level events have happened before, and will happen again.
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Old 14-January-2009, 05:44 PM
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Quote:
Originally Posted by BigDon View Post
Most people think of colonizing space as if we were little fishies going from a lake in Iowa to a lake in California. When in actuality you are going from said lake in Iowa to which you are perfectly adapted to, into somebodies fishtank.

Ever see a fishtank you would drink out of?
I wouldn't know since I don't drink like a fish.

Quote:
Originally Posted by BigDon
Even after a Chixilub sized event the Earth is STILL more habitable than Mars or Venus ever will be.
Habitable for small animals maybe, but maybe not for moderate to large animals.

Quote:
Originally Posted by The Supreme Canuck
Demographically, overpopulation is a myth. Birthrates are already below replacement levels in the vast majority of the developed world, and as developing countries begin to match pace, their birthrates will fall, too. I believe that the UN projects the human population to cap out in the mid-2020s, with the population falling after that.
Unless something changes. With the economy in free-fall people may decide to save their money and make their own entertainment, if you catch my meaning... especially with a long, cold winter still ahead of us.
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Old 14-January-2009, 06:10 PM
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Unless something changes. With the economy in free-fall people may decide to save their money and make their own entertainment, if you catch my meaning... especially with a long, cold winter still ahead of us.
Of course. But the projection stands, as it is.
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Old 14-January-2009, 06:26 PM
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Habitable for small animals maybe, but maybe not for moderate to large animals.
Good thing humans rely on more than just size immunity to survive catastrophe, eh friend?

(Everybody knows I'm merely playing Devil's Advocate, right?)
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Old 16-January-2009, 05:08 PM
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Good thing humans rely on more than just size immunity to survive catastrophe, eh friend?

(Everybody knows I'm merely playing Devil's Advocate, right?)
True, we could survive the initial cataclysm of fire and later ice by hiding underground. If we come out soon enough after the strike, we might be able to round up some insta-barbeque and save it to get through the next several years.
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