Orbiter would be put on autopilot at about 25,000 ft. NASA estimates crew of eight could bail out within 90 sec (about 12 sec per crewmember), which should be completed before reaching 10,000 ft.
From that point the vehicle would take approx 90 more sec. to descend to 2,000 ft (180 sec. total from beginning sequence). So there should be additional time in case someone was slow.
http://spaceflight.nasa.gov/shuttle/.../inflight.html
Despite the limitations it's vastly better than before Challenger when the only option was an ocean ditching, considered non-survivable for structural reasons.